Zeker Weten diagnostiek@Rijnstate

20 september 2016

Vanaf 15 september heeft Rijnstate één centrum voor alle diagnostische onderzoeken die door onder andere huisartsen en verloskundigen worden aangevraagd. Deze diagnostische onderzoeken worden uitgevoerd onder de nieuwe naam ‘ZekerWeten, diagnostiek@rijnstate’. Lees meer

Publicatie met co-auteur vanuit Pathologie-DNA

19 september 2016

Early conversion to prednisolone/everolimus as an alternative weaning regimen associates with beneficial renal transplant histology and function: the randomized-controlled MECANO trial. Lees meer

Management of patients with T1b esophageal adenocarcinoma

15 juli 2016

Esophagectomy for submucosal (T1b) esophageal adenocarcinoma (EAC) is performed in order to optimize patient outcomes given the risk of concurrent lymph node metastases (LNM). However, not seldom, comorbidity precludes these patients from surgery. Therefore, the aim of our study was to assess the course of follow-up after treatment in submucosal EAC patients undergoing surgery versus conservative therapy and to evaluate the incidence of metastatic disease. Lees meer

Publicatie Multicentre evaluation of multidisciplinary team meetingagreement on diagnosis in diff use parenchymal lung disease

30 mei 2016

Diffuse parenchymal lung disease represents a diverse and challenging group of pulmonary disorders. A consistent diagnostic approach to diff use parenchymal lung disease is crucial if clinical trial data are to be applied to individual patients. We aimed to evaluate inter-multidisciplinary team agreement for the diagnosis of diffuse parenchymal lung disease. Lees meer

Molecular clonality assessment shows high performance to predict malignant B-cell non-Hodgkin's lymphoma using cytological smears

23 mei 2016

Molecular PCR-based clonality analysis is helpful for identification of monoclonal B-cell or T-cell populations and to distinguish malignant lymphoma from reactive lymphoid hyperplasia. Typically, clonality assessment on fine-needle aspiration cytology (FNAC) requires freshly obtained aspirates, but the collection and processing of these samples are often challenging in daily practice. In this study, we assessed the routine diagnostic value of the EuroClonality/BIOMED-2 assay for B-cell clonality on air-dried archived Giemsa-stained smears Lees meer

TINF2 Gene Mutation in a Patient with Pulmonary Fibrosis

02 mei 2016

heterozygous Ser245Tyr mutation in the TINF2 gene of a sporadic pulmonary fibrosis patient. This case represents another association between TINF2 mutations and pulmonary fibrosis. Furthermore, this case illustrates the importance of telomere dysfunction and not telomere length alone in telomere syndromes and draws attention to hypogammaglobulinemia as a manifestation of telomere syndromes. Lees meer